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Publications

2023

Bona fide dendritic cells are pivotal precursors for osteoclasts. Ann Rheum Dis.

Amino acids fuel fibroblast-like synoviocyte activation and arthritis by regulating chemokine expression and leukocyte migration. Arthritis Rheumatol

The accelerated waning of immunity and reduced effect of booster in patients treated with bDMARD and tsDMARD after SARS-CoV-2 mRNA vaccination. Front Med (Lausanne),

2022

Immune response after mRNA COVID-19 vaccination in heart transplant recipients: long-term follow-up and evaluation of a third vaccination. Eur J Prev Cardiol,

Immune Response after mRNA COVID-19 Vaccination in Lung Transplant Recipients: A 6-Month Follow-Up. Vaccines (Basel).

COVID-19 as a putative trigger of anti-MDA5-associated dermatomyositis with acute respiratory distress syndrome (ARDS) requiring lung transplantation, a case report. BMC Rheumatol.

Analysis of combined deficiency of interleukin-1 and -6 versus single deficiencies in TNF-mediated arthritis and systemic bone loss. Bone Joint Res.

Immunogenicity of COVID-19 Vaccinations in Hematological Patients: 6-Month Follow-Up and Evaluation of a 3rd Vaccination. Cancers (Basel).

Response to SARS-CoV-2 vaccination in systemic autoimmune rheumatic disease depends on immunosuppressive regimen: a matched, prospective cohort study. Ann Rheum Dis.

Functional Analysis of Autoantibody Signatures in Rheumatoid Arthritis. Molecules.

Importance of the second SARS-CoV-2 vaccination dose for achieving serological response in patients with rheumatoid arthritis and seronegative spondyloarthritis. Ann Rheum Dis.

Trajectory clusters of radiographic progression in patients with rheumatoid arthritis: associations with clinical variables. Ann Rheum Dis.

2021

Presence of anti-acetylated peptide antibodies (AAPA) in inflammatory arthritis and other rheumatic diseases suggests discriminative diagnostic capacity towards early rheumatoid arthritis. Ther Adv Musculoskelet Dis.

SARS-CoV-2 vaccination in rituximab-treated patients: B cells promote humoral immune responses in the presence of T-cell-mediated immunity. Ann Rheum Dis.

'SMASH' recommendations for standardised microscopic arthritis scoring of histological sections from inflammatory arthritis animal models. Ann Rheum Dis.

NKG2D ligands in inflammatory joint diseases: analysis in human samples and mouse models. Clin Exp Rheumatol.

2020

microRNA-146a controls age-related bone loss. Aging Cell.

Biologicals and small molecules for rheumatoid arthritis. Z Rheumatol.

Environmental arginine controls multinuclear giant cell metabolism and formation. Nat Commun.

Innate immunity as the trigger of systemic autoimmune diseases. J Autoimmun.

2019

MicroRNA-155 Controls T Helper Cell Activation During Viral Infection. Front Immunol.

2018

CCR6 controls autoimmune but not innate immunity-driven experimental arthritis. J Cell Mol Med.

Non-classical monocytes as mediators of tissue destruction in arthritis. Ann Rheum Dis.

Extracellular Purine Metabolism Is the Switchboard of Immunosuppressive Macrophages and a Novel Target to Treat Diseases With Macrophage Imbalances. Front Immunol.

Determination of Autoantibody Isotypes Increases the Sensitivity of Serodiagnostics in Rheumatoid Arthritis. Front Immunol.

2017

Therapeutic Modulation of Plasmacytoid Dendritic Cells in Experimental Arthritis. Arthritis Rheumatol.

MicroRNA 155-deficiency leads to decreased autoantibody levels and reduced severity of nephritis and pneumonitis in pristane-induced lupus. PLoS One.

MicroRNA-146a governs fibroblast activation and joint pathology in arthritis. J Autoimmun.

Chronic signaling via the metabolic checkpoint kinase mTORC1 induces macrophage granuloma formation and marks sarcoidosis progression. Nat Immunol.

Regulation of autoantibody activity by the IL-23-TH17 axis determines the onset of autoimmune disease. Nat Immunol.

The soluble cytoplasmic tail of CD45 (ct-CD45) in human plasma contributes to keep T cells in a quiescent state. Eur J Immunol.

2016

Therapeutic implications of autoantibodies in rheumatoid arthritis. RMD Open.

Reduced DICER1 Expression Bestows Rheumatoid Arthritis Synoviocytes Proinflammatory Properties and Resistance to Apoptotic Stimuli. Arthritis Rheumatol.

Abatacept (CTLA-4Ig) treatment reduces T cell apoptosis and regulatory T cell suppression in patients with rheumatoid arthritis. Rheumatology (Oxford).

Nicotinic acetylcholine receptors modulate osteoclastogenesis. Arthritis Res Ther.

2015

Phosphatase and tensin homolog (PTEN) in antigen-presenting cells controls Th17-mediated autoimmune arthritis. Arthritis Res Ther.

Loss of Phosphatase and Tensin Homolog in APCs Impedes Th17-Mediated Autoimmune Encephalomyelitis. J Immunol.

The Lipid-Modifying Enzyme SMPDL3B Negatively Regulates Innate Immunity. Cell Rep.

The MAPK-Activated Kinase MK2 Attenuates Dendritic Cell-Mediated Th1 Differentiation and Autoimmune Encephalomyelitis. J Immunol.

12/15-Lipoxygenase-mediated enzymatic lipid oxidation regulates DC maturation and function. J Clin Invest.

IL-6 blockade in chronic inflammatory diseases. Wien Med Wochenschr.

Loss of phosphatase and tensin homolog (PTEN) in myeloid cells controls inflammatory bone destruction by regulating the osteoclastogenic potential of myeloid cells. Ann Rheum Dis.

2014

Mechanisms of tissue damage in arthritis. Semin Immunopathol.

Macrophage PTEN regulates expression and secretion of arginase I modulating innate and adaptive immune responses. J Immunol.

CD4⁺CD25⁻Foxp3⁺ T cells: a marker for lupus nephritis? Arthritis Res Ther.

2013

B-cell targeted therapeutics in clinical development. Arthritis Res Ther.

Tumor necrosis factor-inhibiting therapy preferentially targets bone destruction but not synovial inflammation in a tumor necrosis factor-driven model of rheumatoid arthritis. Arthritis Rheum.

2012

Targeting TNF receptors in rheumatoid arthritis. Int Immunol.

Interferon signals and monocytic sensitization of the interferon-γ signaling pathway in the peripheral blood of patients with rheumatoid arthritis. Arthritis Rheum.

2011

Essential role of microRNA-155 in the pathogenesis of autoimmune arthritis in mice. Arthritis Rheum.

2010

CD14 is a coreceptor of Toll-like receptors 7 and 9. J Exp Med.

Antiinflammatory effects of tumor necrosis factor on hematopoietic cells in a murine model of erosive arthritis. Arthritis Rheum.

2009

Epigenetic regulation of dendritic cell differentiation and function by oxidized phospholipids. Blood.

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome. Nat Immunol.

Multi-hit inhibition of circulating and cell-associated components of the toll-like receptor 4 pathway by oxidized phospholipids. Arterioscler Thromb Vasc Biol.

2008

The oxidation state of phospholipids controls the oxidative burst in neutrophil granulocytes. J Immunol.