Balcar L, Semmler G, Pomej K, Simbrunner B, Bauer D, Hartl L, Jachs M, Paternostro R, Bucsics T, Pinter M, Trauner M, Mandorfer M, Reiberger T, Scheiner B.
Patterns of acute decompensation in hospitalized patients with cirrhosis and course of acute-on-chronic liver failure.
United European Gastroenterol J. 2021 May;9(4):427-437. doi: 10.1002/ueg2.12089.
Baumgartner M, Lang M, Holley H, Crepaz D, Hausmann B, Pjevac P, Moser D, Haller F, Hof F, Beer A, Orgler E, Frick A, Khare V, Evstatiev R, Strohmaier S, Primas C, Dolak W, Köcher T, Kristaps K, Rath T, Neurath MF, Berry D, Makristathis A, Muttenthaler M, Gasche C.
Mucosal biofilms are an endoscopic feature of irritable bowel syndrome and ulcerative colitis.
Gastroenterology. 2021 Jun 16:S0016-5085(21)03138-3.
Bauer D, Farthofer A, Chromy D, Simbrunner B, Steininger L, Schmidbauer C, Binter T, Trauner M, Mandorfer M, Schmidt R, Mayer F, Holzmann H, Strassl R, Reiberger T.
Recent outbreaks of severe hepatitis A virus infections in Vienna.
Eur J Clin Microbiol Infect Dis. 2021 Feb;40(2):335-344.
Dixon ED, Nardo AD, Claudel T, Trauner M.
The Role of Lipid Sensing Nuclear Receptors (PPARs and LXR) and Metabolic Lipases in Obesity, Diabetes and NAFLD.
Genes (Basel). 2021 Apr 26;12(5):645. doi: 10.3390/genes12050645.
Eser A, Reinisch W, Schreiber S, Ahmad T, Boulos S, Mould DR.
Increased Induction Infliximab Clearance Predicts Early Antidrug Antibody Detection.
J Clin Pharmacol. 2021 Feb;61(2):224-233. doi: 10.1002/jcph.1732.
Evstatiev R, Cervenka A, Austerlitz T, Deim G, Baumgartner M, Beer A, Krnjic A, Gmainer C, Lang M, Frick A, Schachner H, Khare V, Gasche C.
The food additive EDTA aggravates colitis and colon carcinogenesis in mouse models.
Sci Rep. 2021 Mar 4;11(1):5188. doi: 10.1038/s41598-021-84571-5.
Fabian E, Wenisch C, Eisner F, Muhr T, Bauer PK, Prein K, Maierhofer U, Lax SF, Krause R, Zollner G, Weihs W, Krejs GJ.
Clinical-Pathological Conference Series from the Medical University of Graz : Case No 164:
A 46-year-old man with abdominal pain, dyspnea and rapidly progressing multiorgan failure.
Wien Klin Wochenschr. 2021 Apr 19:1-10. doi: 10.1007/s00508-021-01841-y.
Fabian E, Kump P, Schiller D, Brcic I, Gruber C, Heitz PU, Klöppel G, Lipp RW, Moinfar F, Schöfl R, Fickert P, Krejs GJ.
Clinical-Pathological Conference Series from the Medical University of Graz : Case No 173: A 77-year-old patient with adenocarcinoma of the prostate, liver metastases and watery diarrhea.
Wien Klin Wochenschr. 2021 May;133(9-10):515-522. doi: 10.1007/s00508-020-01791-x.
Frick A, Khare V, Jimenez K, Dammann K, Lang M, Krnjic A, Gmainer C, Baumgartner M, Mesteri I, Gasche C.
A Novel PAK1-Notch1 Axis Regulates Crypt Homeostasis in Intestinal Inflammation.
Cell Mol Gastroenterol Hepatol. 2021;11(3):892-907.e1. doi: 10.1016/j.jcmgh.2020.11.001.
Haller F, Gasche C.
Endoscopic retrograde appendicitis therapy: new approach in the treatment of stump appendicitis.
Endoscopy. 2021 Feb 16. doi: 10.1055/a-1346-8677.
Hammer K, Hasanagic H, Memaran N, Huber WD, Hammer J.
Relevance of Methane and Carbon Dioxide Evaluation in Breath Tests for Carbohydrate Malabsorption in a Paediatric Cohort.
J Pediatr Gastroenterol Nutr. 2021 Mar 1;72(3):e71-e77. doi: 10.1097/MPG.0000000000003004.
Hartl L, Jachs M, Desbalmes C, Schaufler D, Simbrunner B, Paternostro R, Schwabl P, Bauer DJM, Semmler G, Scheiner B, Bucsics T, Eigenbauer E, Marculescu R, Szekeres T, Peck-Radosavljevic M, Kastl S, Trauner M, Mandorfer M, Reiberger T.
The differential activation of cardiovascular hormones across distinct stages of portal hypertension predicts clinical outcomes.
Hepatol Int. 2021 May 21. doi: 10.1007/s12072-021-10203-9
Hartl L, Semmler G, Hofer BS, Schirwani N, Jachs M, Simbrunner B, Bauer DJM, Binter T, Pomej K, Pinter M, Trauner M, Mandorfer M, Reiberger T, Scheiner B.
COVID-19-related downscaling of in-hospital liver care decreased patient satisfaction and increased liver-related mortality.
Hepatol Commun. 2021 May 18:10.1002/hep4.1758. doi: 10.1002/hep4.1758.
Jachs M, Binter T, Chromy D, Schalk H, Pichler K, Bauer D, Simbrunner B, Hartl L, Schmidbauer C, Mayer F, Strassl R, Mandorfer M, Gschwantler M, Reiberger T.
Outcomes of an HCV elimination program targeting the Viennese MSM population.
Wien Klin Wochenschr. 2021 Jun 28.
Jimenez K, Leitner F, Leitner A, Scharbert G, Schwabl P, Kramer AM, Krnjic A, Friske J, Helbich T, Evstatiev R, Khare V, Gasche C.
Iron deficiency-induced thrombocytosis increases thrombotic tendency in rats.
Haematologica. 2021 Mar 1;106(3):782-794. doi: 10.3324/haematol.2019.245092.
Kutschera M, Waldhör T, Gröchenig HP, Haas T, Wenzl H, Steiner P, Koch R, Feichtenschlager T, Eckhardt G, Mayer A, Kirchgatterer A, Ludwiczek O, Platzer R, Papay P, Gartner J, Fuchssteiner H, Peters PG, Reicht G, Moser G, Dejaco C, Vogelsang H, Primas C, Novacek G, Miehsler W; Austrian IBD Study Group.
Use of complementary and alternative medicine and low quality of life associate with the need for psychological and psychotherapeutic interventions in inflammatory bowel disease.
United European Gastroenterol J. 2021 Feb;9(1):72-81. doi: 10.1177/2050640620946874.
Thaler J, Lisman T, Quehenberger P, Hell L, Schwabl P, Scheiner B, Ay C, Bucsics T, Reihberger T, Pabinger I, Nieuwland R, Trauner M, Mandorfer M.
Intraperitoneal activation of coagulation and fibrinolysis in patients with cirrhosis and ascites.
Thromb Haemost. 2021 May 21. doi: 10.1055/a-1515-9529.
Mandorfer M, Turon F, Lens S, Baiges A, García-Criado Á, Darnell A, Belmonte E, Ferrusquía-Acosta J, Magaz M, Perez-Campuzano V, Olivas P, Bauer D, Casanovas G, Torres F, Mariño Z, Forns X, Hernández-Gea V, García-Pagán JC.
Risk of non-tumoral portal vein thrombosis in patients with HCV-induced cirrhosis after sustained virological response.
Liver Int. 2021 Jul 9. doi: 10.1111/liv.15009.
Nardo AD, Schneeweiss-Gleixner M, Bakail M, Dixon ED, Lax SF, Trauner M.
Pathophysiological mechanisms of liver injury in COVID-19.
Liver Int. 2021 Jan;41(1):20-32. doi: 10.1111/liv.14730.
Paternostro R, Traussnigg S, Staufer K, Mandorfer M, Halilbasic E, Lagler H, Stift J, Wrba F, Munda P, Trauner M.
Prevalence of anti-Hepatitis E antibodies and impact on disease severity in non-alcoholic fatty liver disease.
Hepatol Res. 2021 Jan;51(1):69-79. doi: 10.1111/hepr.13581.
Paternostro R, Bardach C, Hofer BS, Scheiner B, Schwabl P, Asenbaum U, Ba-Ssalamah A, Scharitzer M, Bucscis T, Simbrunner B, Bauer D, Trauner M, Mandorfer M, Reiberger T, Lampichler K.
Prognostic impact of sarcopenia in cirrhotic patients stratified by different severity of portal hypertension.
Liver Int. 2021 Apr;41(4):799-809. doi: 10.1111/liv.14758.
Paternostro R, Staufer K, Traussnigg S, Stättermayer AF, Halilbasic E, Keritam O, Meyer EL, Stift J, Wrba F, Sipos B, Canbay A, Schlattjan M, Aigner E, Datz C, Stickel F, Schafmayer C, Hampe J, Buch S, Prager G, Munda P, Mandorfer M, Ferenci P, Trauner M.
Combined effects of PNPLA3, TM6SF2 and HSD17B13 variants on severity of biopsy-proven non-alcoholic fatty liver disease.
Hepatol Int. 2021 Jun 2. doi: 10.1007/s12072-021-10200-y.
Pfisterer N, Schmidbauer C, Riedl F, Maieron A, Stadlbauer V, Hennlich B, Schwarzer R, Puespoek A, Bucsics T, Effenberger M, Bota S, Gschwantler M, Peck-Radosavljevic M, Mandorfer M, Madl C, Trauner M, Reiberger T.
Perceptions on the management of varices and on the use of albumin in patients with cirrhosis among GI specialists in Austria.
Wien Klin Wochenschr. 2021 May;133(9-10):421-431. doi: 10.1007/s00508-020-01769-9.
Costa D, Simbrunner B, Jachs M, Hartl L, Bauer D, Paternostro R, Schwabl P, Scheiner B, Stättermayer AF, Pinter M, Trauner M, Mandorfer M, Reiberger T.
Systemic inflammation increases across distinct stages of advanced chronic liver disease and correlates with decompensation and mortality.
J Hepatol. 2021 Apr;74(4):819-828. doi: 10.1016/j.jhep.2020.10.004.
Steininger L, Chromy D, Bauer D, Simbrunner B, Binter T, Schwabl P, Schmidbauer C, Trauner M, Gschwantler M, Mandorfer M, Reiberger T.
Direct patient-physician communication via a hepatitis C hotline facilitates treatment initiation in patients with poor adherence.
Wien Klin Wochenschr. 2021 May;133(9-10):452-460. doi: 10.1007/s00508-020-01790-y.
Narula N, Aruljothy A, Wong ECL, Homenauth R, Alshahrani AA, Marshall JK, Reinisch W.
The impact of ustekinumab on extraintestinal manifestations of Crohn's disease: A post hoc analysis of the UNITI studies.
United European Gastroenterol J. 2021 Jun 2. doi: 10.1002/ueg2.12094.
Narula N, Wong ECL, Dulai PS, Sengupta NK, Marshall JK, Colombel JF, Reinisch W.
Comparative Efficacy and Rapidity of Action for Infliximab vs Ustekinumab in Biologic Naïve Crohn's Disease.
Clin Gastroenterol Hepatol. 2021 Apr 7:S1542-3565(21)00394-3. doi: 10.1016/j.cgh.2021.04.006.
Narula N, Wong ECL, Dulai PS, Marshall JK, Colombel JF, Reinisch W.
Outcomes of Passable and Non-Passable Strictures in Clinical Trials of Crohn's Disease: A Post-hoc Analysis.
J Crohns Colitis. 2021 Mar 6:jjab045. doi: 10.1093/ecco-jcc/jjab045
Narula N, Wong ECL, Dulai PS, Marshall JK, Colombel JF, Reinisch W.
Week 6 Calprotectin Best Predicts Likelihood of Long-term Endoscopic Healing in Crohn's Disease: A Post-hoc Analysis of the UNITI/IM-UNITI Trials.
J Crohns Colitis. 2021 Mar 5;15(3):462-470. doi: 10.1093/ecco-jcc/jjaa189.
Gottlieb K, Daperno M, Usiskin K, Sands BE, Ahmad H, Howden CW, Karnes W, Oh YS, Modesto I, Marano C, Stidham RW, Reinisch W.
Endoscopy and central reading in inflammatory bowel disease clinical trials: achievements, challenges and future developments.
Gut. 2021 Feb;70(2):418-426. doi: 10.1136/gutjnl-2020-320690.
Reinisch W, Gecse K, Halfvarson J, Irving PM, Jahnsen J, Peyrin-Biroulet L, Rogler G, Schreiber S, Danese S.
Clinical Practice of Adalimumab and Infliximab Biosimilar Treatment in Adult Patients With Crohn's Disease.
Inflamm Bowel Dis. 2021 Jan 1;27(1):106-122. doi: 10.1093/ibd/izaa078.
Reinisch W, Mishkin DS, Oh YS, Schreiber S, Hussain F, Jacob R, Hassanali A, Daperno M.
Impact of various central endoscopy reading models on treatment outcome in Crohn's disease using data from the randomized, controlled, exploratory cohort arm of the BERGAMOT trial.
Gastrointest Endosc. 2021 Jan;93(1):174-182.e2. doi: 10.1016/j.gie.2020.05.020.
Scharrer S, Primas C, Eichinger S, Tonko S, Kutschera M, Koch R, Blesl A, Reinisch W, Mayer A, Haas T, Feichtenschlager T, Fuchssteiner H, Steiner P, Ludwiczek O, Platzer R, Miehsler W, Tillinger W, Apostol S, Schmid A, Schweiger K, Vogelsang H, Dejaco C, Herkner H, Novacek G; Austrian IBD Study Group.
Inflammatory Bowel Disease and Risk of Major Bleeding During Anticoagulation for Venous Thromboembolism.
Inflamm Bowel Dis. 2021 Jan 2:izaa337. doi: 10.1093/ibd/izaa337
Scharrer S, Lissner D, Primas C, Reinisch W, Novacek G, Reinisch S, Papay P, Dejaco C, Vogelsang H, Miehsler W.
Passive Smoking Increases the Risk for Intestinal Surgeries in Patients With Crohn's Disease.
Inflamm Bowel Dis. 2021 Feb 16;27(3):379-385. doi: 10.1093/ibd/izaa117.
Scharrer S, Kutschera M, Weseslindtner L, Primas C, Vogelsang H.
Humoral response to COVID-19 infection in immunosuppressed patients with inflammatory bowel disease.
Eur J Gastroenterol Hepatol. 2021 Mar 1;33(3):443-447. doi: 10.1097/MEG.0000000000002094.
Scharrer S, Primas C, Eichinger S, Tonko S, Kutschera M, Koch R, Blesl A, Reinisch W, Mayer A, Haas T, Feichtenschlager T, Fuchssteiner H, Steiner P, Ludwiczek O, Platzer R, Miehsler W, Tillinger W, Apostol S, Schmid A, Schweiger K, Vogelsang H, Dejaco C, Herkner H, Novacek G; Austrian IBD Study Group.
Inflammatory Bowel Disease and Risk of Major Bleeding During Anticoagulation for Venous Thromboembolism.
Inflamm Bowel Dis. 2021 Jan 2:izaa337. doi: 10.1093/ibd/izaa337.
Eder M, Omic H, Gorges J, Badt F, Kikic Z, Saemann MD, Tong A, Bauer D, Semmler G, Reiberger T, Lagler H, Scheiner B.
Influenza vaccination uptake and factors influencing vaccination decision among patients with chronic kidney or liver disease.
PLoS One. 2021 Apr 13;16(4):e0249785. doi: 10.1371/journal.pone.0249785.
Schmidbauer C, Schwarz M, Schütz A, Schubert R, Schwanke C, Gutic E, Pirker R, Lang T, Reiberger T, Haltmayer H, Gschwantler M.
Directly observed therapy at opioid substitution facilities using sofosbuvir/velpatasvir results in excellent SVR12 rates in PWIDs at high risk for non-adherence to DAA therapy.
PLoS One. 2021 Jun 4;16(6):e0252274. doi: 10.1371/journal.pone.0252274.
Schneeweiss-Gleixner M, Greiner G, Herndlhofer S, Schellnegger J, Krauth MT, Gleixner KV, Wimazal F, Steinhauser C, Kundi M, Thalhammer R, Schwarzinger I, Hoermann G, Esterbauer H, Födinger M, Valent P, Sperr WR.
Impact of HFE gene variants on iron overload, overall survival and leukemia-free survival in myelodysplastic syndromes.
Am J Cancer Res. 2021 Mar 1;11(3):955-967. e
Schwabl P, Hambruch E, Budas GR, Supper P, Burnet M, Liles JT, Birkel M, Brusilovskaya K, Königshofer P, Peck-Radosavljevic M, Watkins WJ, Trauner M, Breckenridge DG, Kremoser C, Reiberger T.
The Non-Steroidal FXR Agonist Cilofexor Improves Portal Hypertension and Reduces Hepatic Fibrosis in a Rat NASH Model.
Biomedicines. 2021 Jan 9;9(1):60. doi: 10.3390/biomedicines9010060.
Semmler G, Binter T, Kozbial K, Schwabl P, Hametner-Schreil S, Zanetto A, Gavasso S, Chromy D, Bauer DJM, Simbrunner B, Scheiner B, Bucsics T, Stättermayer AF, Pinter M, Steindl-Munda P, Schöfl R, Russo FP, Simioni P, Trauner M, Ferenci P, Reiberger T, Mandorfer M.
Noninvasive Risk Stratification After HCV Eradication in Patients With Advanced Chronic Liver Disease.
Hepatology. 2021 Apr;73(4):1275-1289. doi: 10.1002/hep.31462.
Semmler G, Wernly S, Bachmayer S, Leitner I, Wernly B, Egger M, Schwenoha L, Datz L, Balcar L, Semmler M, Stickel F, Niederseer D, Aigner E, Datz C.
Metabolic dysfunction-associated fatty liver disease (MAFLD) - rather a bystander than a driver of mortality.
J Clin Endocrinol Metab. 2021 May 13:dgab339. doi: 10.1210/clinem/dgab339.
Semmler G, Binter T, Kozbial K, Schwabl P, Chromy D, Bauer D, Simbrunner B, Müllner-Bucsics T, Scheiner B, Stättermayer A, Pinter M, Steindl-Munda P, Trauner M, Ferenci P, Reiberger T, Mandorfer M.
Influence of Genetic Variants on Disease Regression and Outcomes in HCV-Related Advanced Chronic Liver Disease after SVR.
J Pers Med. 2021 Apr 7;11(4):281. doi: 10.3390/jpm11040281.
Semmler G, Balcar L, Oberkofler H, Zandanell S, Strasser M, Niederseer D, Feldman A, Stickel F, Strnad P, Datz C, Paulweber B, Aigner E.
PNPLA3 and SERPINA1 Variants Are Associated with Severity of Fatty Liver Disease at First Referral to a Tertiary Center.
J Pers Med. 2021 Mar 1;11(3):165. doi: 10.3390/jpm11030165.
Semmler G, Aberle SW, Griebler H, Richter L, Schmid D, Stiasny K, Holzmann H, Weseslindtner L.
Performance of Four IgM Antibody Assays in the Diagnosis of Measles Virus Primary Infection and Cases with a Serological Profile Indicating Reinfection.
J Clin Microbiol. 2021 Apr 20;59(5):e02047-20. doi: 10.1128/JCM.02047-20.
Semmler G, Traugott MT, Graninger M, Hoepler W, Seitz T, Kelani H, Karolyi M, Pawelka E, Aragón de La Cruz S, Puchhammer-Stöckl E, Aberle SW, Stiasny K, Zoufaly A, Aberle JH, Weseslindtner L.
Assessment of S1-, S2-, and NCP-Specific IgM, IgA, and IgG Antibody Kinetics in Acute SARS-CoV-2 Infection by a Microarray and Twelve Other Immunoassays.
J Clin Microbiol. 2021 Apr 20;59(5):e02890-20. doi: 10.1128/JCM.02890-20.
Semmler G, Barbieri F, Thudt K, Vock P, Mörtl D, Mayr H, Wollmann CG, Adukauskaite A, Pfeifer B, Senoner T, Dichtl W.
Long-Term Technical Performance of the Osypka QT-5® Ventricular Pacemaker Lead.
J Clin Med. 2021 Feb 8;10(4):639. doi: 10.3390/jcm10040639.
Semmler G, Pomej K, Bauer DJM, Balcar L, Simbrunner B, Binter T, Hartl L, Becker J, Pinter M, Quehenberger P, Trauner M, Mandorfer M, Lisman T, Reiberger T, Scheiner B.
Safety of direct oral anticoagulants (DOACs) in patients with advanced liver disease.
Liver Int. 2021 Jun 21. doi: 10.1111/liv.14992.
Simbrunner B, Stadlmann A, Schwabl P, Paternostro R, Bauer DJM, Bucsics T, Scheiner B, Lampichler K, Wöran K, Beer A, Eigenbauer E, Pinter M, Stättermayer AF, Marculescu R, Szekeres T, Trauner M, Mandorfer M, Reiberger T.
Placental growth factor levels neither reflect severity of portal hypertension nor portal-hypertensive gastropathy in patients with advanced chronic liver disease.
Dig Liver Dis. 2021 Mar;53(3):345-352. doi: 10.1016/j.dld.2020.09.006.
Tardelli M, Bruschi FV, Fuchs CD, Claudel T, Auer N, Kunczer V, Ronda OAHO, Verkade HJ, Stojakovic T, Scharnagl H, Trauner M.
Absence of Adiponutrin (PNPLA3) and Monoacylglycerol Lipase Synergistically Increases Weight Gain and Aggravates Steatohepatitis in Mice.
Int J Mol Sci. 2021 Feb 20;22(4):2126. doi: 10.3390/ijms22042126.
Geier A, Tiniakos D, Denk H, Trauner M.
From the origin of NASH to the future of metabolic fatty liver disease.
Gut. 2021 Feb 25:gutjnl-2020-323202. doi: 10.1136/gutjnl-2020-323202.
Lax SF, Skok K, Zechner PM, Setaffy L, Kessler HH, Kaufmann N, Vander K, Cokić N, Maierhofer U, Bargfrieder U, Trauner M.
Systemic consequences and clinical aspects of SARS-CoV-2 infection.
Pathologe. 2021 Mar;42(2):155-163. doi: 10.1007/s00292-021-00913-0.
Lax SF, Skok K, Zechner PM, Trauner M.
Pulmonary Arterial Thrombosis in COVID-19 With Fatal Outcome.
Ann Intern Med. 2021 Jan;174(1):139-140. doi: 10.7326/L20-1276
Pötter-Lang S, Ba-Ssalamah A, Bastati N, Messner A, Kristic A, Ambros R, Herold A, Hodge J, Trauner M.
Modern imaging of cholangitis.
Br J Radiol. 2021 Jul 8:20210417. doi: 10.1259/bjr.20210417.
Traussnigg S, Halilbasic E, Hofer H, Munda P, Stojakovic T, Fauler G, Kashofer K, Krssak M, Wolzt M, Trauner M.
Open-label phase II study evaluating safety and efficacy of the non-steroidal farnesoid X receptor agonist PX-104 in non-alcoholic fatty liver disease.
Wien Klin Wochenschr. 2021 May;133(9-10):441-451. doi: 10.1007/s00508-020-01735-5
Waldmann EA, Kammerlander AA, Gessl I, Penz D, Majcher B, Hinterberger A, Bretthauer M, Trauner MH, Ferlitsch M.
Association of Adenoma Detection Rate and Adenoma Characteristics With Colorectal Cancer Mortality After Screening Colonoscopy.
Clin Gastroenterol Hepatol. 2021 Apr 18:S1542-3565(21)00457-2. doi: 10.1016/j.cgh.2021.04.023.
Waldmann E, Penz D, Šinkovec H, Heinze G, Rinner C, Jiricka L, Majcher B, Hinterberger A, Trauner M, Ferlitsch M.
Interval cancer after colonoscopy in the Austrian National Screening Programme: influence of physician and patient factors.
Gut. 2021 Jul;70(7):1309-1317. doi: 10.1136/gutjnl-2019-319427.
Zhu C, Boucheron N, Müller AC, Májek P, Claudel T, Halilbasic E, Baazim H, Lercher A, Viczenczova C, Hainberger D, Preglej T, Sandner L, Alteneder M, Gülich AF, Khan M, Hamminger P, Remetic J, Ohradanova-Repic A, Schatzlmaier P, Donner C, Fuchs CD, Stojakovic T, Scharnagl H, Sakaguchi S, Weichhart T, Bergthaler A, Stockinger H, Ellmeier W, Trauner M.
24-NorUrsodeoxycholic acid reshapes immunometabolism in CD8+ T-cells and alleviates hepatic inflammation.
J Hepatol. 2021 Jul 6:S0168-8278(21)01886-9. doi: 10.1016/j.jhep.2021.06.036.